These donations enable a key set of pre-study pilots ahead of the next phase of LEVF’s groundbreaking investigations into the effects of combining different damage-repair interventions for middle-aged mice.

RMR1, the first phase of this Robust Mouse Rejuvenation project, has been running since February 2023, and is now nearing completion. Mice in this project have received combinations of up to four different treatments.

Caitlin Lewis, Director of Project Pipeline & Strategy at LEVF, commented: These donations come at exactly the right time, as we are ready to commence pre-study pilot trials ahead of RMR2. RMR2, which will involve mice receiving combinations of up to six different life-extension treatments, takes into account significant findings from RMR1. These experiments have the potential to achieve record-breaking extension of both healthspan and lifespan of middle-aged mice, and to catapult longevity intervention combinations into the mainstream and into the clinic.

Didier Coeurnelle commented: The RMR investigations are poised to transform public understanding of the possibilities of treatments to extend healthspan and lifespan, not only in mice, but in humans. These investigations particularly deserve financial support, from anyone who shares my conviction that treating aging is a profoundly urgent humanitarian task. October 1st is the start of Longevity Month, in which longevity advocates around the world place a special focus on the need for faster progress. I hope my own donations can inspire others to consider how they, too, can best help to accelerate the defeat of aging.

Aubrey de Grey, President and CSO of LEVF, replied: “This is a wonderfully generous donation from Didier. Via his previous financial support and his tireless advocacy for more than 15 years, Didier has long been a bold champion of the quest to reverse aging. This is by far the largest donation he has made, and affirms our joint belief that now is the time to greatly expand research to target the underlying processes of aging. Anyone else who wishes to make a donation to support RMR or any of the other activities undertaken by LEVF can do so via the donation page on our website, https://www.levf.org/donate.

Source: https://www.levf.org/october-2024-matching-challenge