4th Edition Global Longevity Federation

Study probes how eating less can extend lifespan

Researchers at The Jackson Laboratory conduct pivotal study into aging and lifespan to uncover new details about how diets might make people live longer — but also their negative side effectsReadmore

SENS Research Foundation and Lifespan.io Announce Intent to Merge, Forming a Novel Longevity Entity

In a groundbreaking announcement set to impact the future of longevity research and outreach, two historic longevity nonprofits – SENS Research Foundation and Lifespan.io (Lifespan Extension Advocacy Foundation) – have unveiled plans to merge, upon completion of regulatory approvals.Readmore

clock.bio Raises $5.3M Seed Funding and Decodes Genetic Atlas of Human Rejuvenation Factors

clock.bio, a healthspan biotech, today announced it has raised $5.3 million in seed funding led by LocalGlobe, with participation from BlueYard Capital, Onsight Ventures, and Dr. Jonathan Milner, the Founder of Abcam. The company has made significant progress in decoding the biology of human rejuvenation, identifying more than 100 genes that jointly constitute an "Atlas of Rejuvenation Factors."Readmore

Integrated Biosciences Raises $17 Million

Silicon Valley biotech Integrated Biosciences has raised $17.2 million in seed financing to develop therapeutics for age-related diseases. The funding round included Sutter Hill Ventures, Lifespan Vision Ventures, Root Ventures, Civilization Ventures, Illumina Ventures Labs and additional funding sources.Readmore

New Research Offers Hope for Preventing Age-Related Blindness

The researchers form University of Rochester discovered that a protein called tissue inhibitor of metalloproteinases 3 (TIMP3) is overproduced in AMD. TIMP3 inhibits the activity of enzymes called matrix metalloproteinases (MMPs), which are essential for eye health. Impaired MMP activity leads to increase in another enzyme which promotes inflammation and the formation of drusen. Readmore

Helaina Raises $45 Million in Series B Funding to Accelerate the Commercialization of Human Bioactive Proteins Starting with effera™ Human Lactoferrin

Helaina has announced a successful $45 million Series B funding round, bringing its total equity funding to $83 million, which will be used to further the development of effera Human Lactoferrin, a protein product designed to support women’s health, active nutrition and healthy aging.Readmore

RYBREVANT® (amivantamab-vmjw) plus standard of care approved in the U.S. as first and only targeted regimen to cut risk of disease progression by more than half in second-line EGFR-mutated advanced lung cancer

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Insilico Medicine reports positive Phase IIa results for ISM001-055, a novel first-in-class drug treatment for idiopathic pulmonary fibrosis (IPF) designed using generative AI

Insilico Medicine, a clinical-stage generative AI-driven drug discovery company, announced positive preliminary results from its Phase IIa clinical trial evaluating ISM001-055. ISM001-055 is a first-in-class small molecule targeting TNIK (Traf2- and Nck-interacting kinase) and was designed utilizing generative AI to treat idiopathic pulmonary fibrosis (IPF). The study met both its primary endpoint of safety and its secondary efficacy endpoints, demonstrating dose-dependent response in forced vital capacity (FVC), a critical measure of lung function in IPF patients.Readmore

Scientists uncover the underlying cause for long Covid symptoms

Scientists have discovered that the long-term symptoms and impact on health experienced by global populations of COVID-19 patients may be a result of a mutation in SARS-CoV-2, the virus that causes the disease. According to the team, the mutations occur after the virus has already infected the human body. This may help to explain the ability of the virus to cause a large variety of different symptoms described as “long COVID”, affecting different tissues in human anatomy long after the initial period of incubation and resulting illness, including the respiratory system, the cardiovascular system and even the central nervous system, and could one day even lead to specific treatments to protect and clear the virus from the brain.Readmore

Miller School Study Highlights Role of Immunometabolism in Aging

This study is the first to demonstrate that metabolic abnormalities in immune cells lead to a reduced ability to generate protective immunity.Readmore

Tulane to lead a $4 million NIH-funded center for aging research

The National Institutes of Health will award up to $4 million over five years to establish a coordinating center for research on aging. Led by the Tulane National Primate Research Center and developed in partnership with the California National Primate Research Center and Baylor College of Medicine, the coordinating center will focus on advancing aging research through studies of nonhuman primates.Readmore

Researchers Link Midlife Blood Biomarkers to Late-life Dementia Risk

A research team led by Priya Palta, PhD, MHS, an associate professor of neurology at the UNC School of Medicine, has found that certain Alzheimer’s disease and neurodegenerative blood biomarkers in midlife and late life had strong associations with late-life dementia.Readmore

Longeveron® Announces U.S. FDA Grants Fast Track Designation for Lomecel-B™ for the Treatment of Mild Alzheimer’s Disease

Longeveron Inc. (NASDAQ: LGVN), a clinical stage regenerative medicine biotechnology company developing cellular therapies for life-threatening and chronic aging-related conditions, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to Lomecel-B™ for the treatment of mild Alzheimer’s Disease. Lomecel-B™ is a proprietary, scalable, allogeneic, investigational cellular therapy being evaluated across multiple indications, including Alzheimer’s Disease (Phase 2a completed), Aging-related Frailty (Phase 2b completed) and hypoplastic left heart syndrome (HLHS) (Phase 2b ongoing).Readmore

Mayo Clinic scientists define new type of memory loss in older adults

Researchers at Mayo Clinic have established new criteria for a memory-loss syndrome in older adults that specifically impacts the brain's limbic system. It can often be mistaken for Alzheimer's disease. The good news: Limbic-predominant Amnestic Neurodegenerative Syndrome, or LANS, progresses more slowly and has a better prognosis, and is now more clearly defined for doctors working to find answers for memory loss patients.Readmore

Massive biomolecular shifts occur in our 40s and 60s, Stanford Medicine researchers find

Time marches on predictably, but biological aging is anything but constant, according to a new Stanford Medicine study.Readmore

Revealing a master controller of development and ageing

University of Queensland researchers have unlocked crucial molecular secrets of ageing in cells, potentially paving the way to improve quality of life as people age.Readmore

Scientists find “master switch” which could hold the key to longer, healthier lives.

Inhibiting IL-11 in mice extends healthy lifespan and reduces hallmarks of diseases associated with ageingReadmore

UTSW study identifies RNA molecule that regulates cellular aging

Researchers discover noncoding RNA that plays unexpected role in senescence, which is involved in aging, degenerative diseases, cancer, other conditionsReadmore

Interleukin Linked to Muscle Loss, Fat Accumulation of Aging

In a new paper appearing in Nature, the team of scientists from Duke-NUS Medical School in Singapore demonstrated in preclinical mouse studies that the protein interleukin-11 (IL11) actively promotes aging, and that giving an anti-IL11 therapy not only counteracts the deleterious effects of aging but also increases lifespan. Readmore

Nutritious diet in midlife linked to healthier aging

Eating a diet rich in fruits, vegetables, whole grains, and unsaturated fats throughout midlife may increase an individual’s odds of aging healthfully, according to a new study by researchers at Harvard T.H. Chan School of Public Health.Readmore

UQ research reveals exercise brain boost can last for years

A longitudinal study by University of Queensland researchers has found high-intensity interval exercise improves brain function in older adults for up to 5 years. Readmore

Eli Lilly's Kisunla™ (donanemab-azbt) Approved by the FDA for the Treatment of Early Symptomatic Alzheimer's Disease

The U.S. Food and Drug Administration (FDA) approved Kisunla™ (donanemab-azbt, 350 mg/20 mL once-monthly injection for IV infusion), Eli Lilly and Company's (NYSE: LLY) Alzheimer's treatment for adults with early symptomatic Alzheimer's disease (AD), which includes people with mild cognitive impairment (MCI) as well as people with the mild dementia stage of AD, with confirmed amyloid pathology.1, 2 Once-monthly Kisunla is the first and only amyloid plaque-targeting therapy with evidence to support stopping therapy when amyloid plaques are removed, which can result in lower treatment costs and fewer infusions.3-6Readmore

Cracking the aging code: Insights into lipid changes

Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered numerous age-related changes in the lipid metabolism of mice, across both organs and sexes. Among these changes was the selective accumulation, throughout the body, of certain lipids produced by gut bacteria as the mice aged. Readmore

Damage to synapses caused by Alzheimer’s disease reversed

A novel treatment has been proven to effectively treat cognitive decline in mice with Alzheimer’s disease.Readmore

“LEQEMBI®” (Lecanemab) for the Treatment of Alzheimer’s Disease Launched in China China is the Third Country to Launch LEQEMBI Following the United States and Japan

Eisai Co., Ltd. and Biogen Inc. (Nasdaq: BIIB, Corporate headquarters: Cambridge, Massachusetts, announced today that the humanized anti-soluble aggregated amyloid-beta monoclonal antibody “LEQEMBI®” has been launched in China. LEQEMBI received approval in January 2024 as a treatment of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and mild AD dementia. China is the third country to launch LEQEMBI following the United States and Japan. Readmore

UNM Center for Memory & Aging Receives $21.7 Million NIH Grant to Fund its Alzheimer’s Disease Research Center

The University of New Mexico’s Center for Memory & Aging has received a five-year $21.7 million program grant from the National Institutes of Health (NIH) to fund its Alzheimer’s Disease Research Center (ADRC).Readmore

VUMC’s Alexander Bick receives a “healthy aging” research award

Vanderbilt’s Alexander Bick, MD, PhD, has received a Hevolution/AFAR New Investigator Award in Aging Biology and Geroscience Research from the American Federation for Aging Research (AFAR) and Hevolution Foundation.Readmore

Risk factors for faster aging in the brain revealed in new study

Researchers from the Nuffield Department of Clinical Neurosciences at the University of Oxford have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable Readmore

Middle-aged brain can predict your future brain health, new review finds

The team led by University College Cork (UCC) researchers reviewed past evidence from human and animal studies to illustrate that during middle age the brain undergoes significant molecular, cellular, and structural changes, and many of these changes haveReadmore

More Schooling is Linked to Slowed Aging and Increased Longevity Two years of education translated to a 2-3 percent slower pace of aging

Participants in the Framingham Heart Study who achieved higher levels of education tended to age more slowly and went on to live longer lives as compared to those who did not achieve upward educational mobility, according to a new study by researchers at Readmore

Researchers Find More Complexity in Aging Brain’s Memory Decline

Researchers from The University of Texas at Dallas Center for Vital Longevity (CVL) have discovered that brain correlates of age-related memory decline are more complicated than previously believed, a finding that could affect efforts to preserve cognitivReadmore

Looking to rewind the aging clock

Harvard researchers create model that better measures biological age, distinguishes between harmful and adaptive changes during life Readmore

Schizophrenia and aging may share a common biological basis Tightly synchronized genetic changes in two types of brain cells may underlie cognitive impairment in both conditions, offering potential therapeutic clues.

Researchers from the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schiReadmore

TELOMIR PHARMACEUTICALS RELEASES NEW PRE-CLINICAL DATA FOR TELOMIR-1 TO BE PRESENTED AT THE GLOBAL LONGEVITY FEDERATION CONFERENCE IN LAS VEGAS ON MARCH 26TH

Poster presentation delivers pre-clinical results that demonstrate that its lead development product, Telomir-1, elongates telomere caps on human normal embryonic fibroblast cells Readmore

Anti-ageing drug rapamycin improves immune function through endolysosomes, Protection against an increase in pro-inflammatory factors with age

A research group at the Max Planck Institute for Biology of Ageing has discovered in fruit flies that rapamycin activates the so-called endolysosomes, which have a similar function to the stomach in our cells.Readmore

£3 million UKRI funding to support research into better health, ageing, and wellbeing

The University of Cambridge has received UKRI funding for research on age-related biological changes in model organisms as part of a national collaboration. Readmore

Damage to cell membranes causes cell aging

A new study has found that mechanical damage to the cell membrane may induce cellular senescence in human cells. Readmore

Could a Drug Prevent Hearing Loss from Loud Music and Aging?

Researchers have found a gene that links deafness to cell death in the inner ear in humans – creating new opportunities for averting hearing loss.Readmore

Keys to aging hidden in the leaves

Scientists have known about a particular organelle in plant cells for over a century. However, UC Riverside scientists have only now discovered that organelle’s key role in aging. Readmore

Life span increases in mice when specific brain cells are activated

Brain cells communicate with fat tissue to produce cellular fuel, counteract effects of agingReadmore

Brock-led research uncovers breakthrough in age-related diseases

Newman Sze, Brock University Professor of Health Sciences and Canada Research Chair in Mechanisms of Health and Disease, leads an international team that has uncovered a key link between oxidative stress, aging and chronic diseases, paving the way for posReadmore