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Scientific Program

Jesse Morse

The Osteoparthic Center, USA [10:30AM-11:00AM]

Title: The Role of Peptides in Anti-Aging

Oral Presentation

Abstract

Definition of Aging
 
Dr. Joseph Cleaver defines aging as “the most insidious and relentless degenerative disease known to man. It is characterized by molecular DNA damage, leading to cell senescence, cell failure, physiologic deterioration resulting in loss of homeostasis led by immune senescence.”
 
- DNA damage and telomere shortening then leads to cell senescence and SASP cells
- What helps with DNA damage repair & prevention of epigenetic drift
- Methylene Blue, Cat’s Claw, NAC, Sulforaphane, Melatonin, Curcumin,
NAD/NMN, SIRT 6 modulators, Berberine, Resveratrol, Fucoidan, Astaxanthin, Urolithin A, EGCG, Peptides - What is a senescent cell?
- Cell cycle arrest phase G0. Can’t divide but still viable, but apoptosis doesn’t occur
- Accelerators of Senescence: Lifestyle & Environment
- Epigenetic factors, Telomere Erosion, DNA damage, Mitochondrial dysfunction, Nutrient signaling dysfunction, Chronic inflammation, Stem Cell exhaustion, Proteostatic dysfunction - Signs of aging
- Frailty, DMII, Loss of kidney function, Dementia, Osteoporosis, Osteoarthritis, Cancers, Skin aging (wrinkles, sagging), Hair loss - Immune Aging Panel:
- T-Cell Ratio (CD4/CD8): Optimal = 1.5 - 2.5, Healthy = 2.5+, - Aging = 1-1.5, Immune risk = 0.7-1, Critical IRP = <0.7 - What are peptides?
- Short chains of amino acids
- How they work
- Classes of peptides
- Musculoskeletal (tissue healing)
- Aesthetics
- Muscle health / sarcopenia / Weight loss
- Sexual performance
- Anti-Aging: Sermorelin, GhkCu, BPC-157, MOTs-C, 5 Amnio 1-QM,
Dihexa, Cerebrolysin, TB-4, TA-1
- Neuro-regeneration
- Sports performance
- Heart
- Side effects
- Uses in Longevity / Functional / Regenerative medicine
- General principles of peptides
- Examples of classes & peptides
- DDR: DNA Damage / Telomere - Epitalon, GHKCu
- Immune System Health - TA-1, TB-500, BPC-157
- Latent Viral Therapy - LL-37, BPC-157
- Mitochondria - SS-31, MOTs-C, CJC-1295/Ipa, Semorelin, Epitalon
- Telomere Length - Epitalon
- Senolytic - FOXO4 DRI
- Longevity: Immune/Pineal/Thymus - TA-1, TB-4, SS-21, Epitalon, Thymulin

Biography

Dr. Jesse Morse is board-certified in family and sports medicine that specializes in injuries and musculoskeletal pain. He uses a combination of traditional orthopedic medicine with regenerative medicine to provide an all-inclusive approach to injuries. Rather than providing a temporary solution, Dr. Morse identifies the root of the pain, and designs a treatment plan to comprehensively correct the cause and provide a solution.

A former team physician, Dr. Morse approaches medicine in an appropriately aggressive yet preventative fashion, custom-designing treatment plans that treat the current injury, preventing the injury from worsening as well as new compensatory injuries from developing. An athlete himself, Dr. Morse treats all different types of patients, ranging from weekend warriors to professional athletes. He understands the comprehensive approach it takes to get the patient back happy and healthy.

Dr. Morse is a newcomer to the Integrative Medicine scene, but is a fast learner. He believes that the majority of the diseases and illnesses humans develop have to do with weakened immune systems and various toxins that we have come into contact with. His goal is to identify what is causing your body to underperform, generate fatigue or pain, and help correct it. Dr. Morse has an interest in anti-aging / longevity medicine, fantasy football, and is always looking for different research-backed ways to optimize our health. 

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