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USC researchers define brain scan marker to better classify Alzheimer’s disease-related changes

Published on: Jun 26, 2025

Researchers from the Keck School of Medicine of USC’s Stevens Neuroimaging and Informatics Institute have identified a new tau PET imaging cut-point that may enhance early detection of Alzheimer’s disease (AD). Published in Imaging Neuroscience, the study—part of the Health and Aging Brain Study–Health Disparities (HABS-HD)—analyzed over 675 older adults to find biologically relevant thresholds of tau buildup in the brain.

Using the 18F-PI-2620 tracer, researchers found that high tau levels in the medial temporal lobe significantly indicated cognitive impairment—but only when amyloid buildup was also present, and only in Hispanic and non-Hispanic White participants. In non-Hispanic Black participants, this marker did not reliably predict cognitive decline, suggesting that other biological or social factors may be involved.

These findings underscore the need for inclusive research and tailored diagnostics, said senior author Dr. Meredith Braskie. Lead author Victoria Tennant added that this cut-point is a promising tool for both clinical and research settings, although further work is needed to ensure its effectiveness across populations.

The study reinforces the importance of tau imaging in identifying those at risk for AD and supports the growing push for more personalized, equitable approaches to Alzheimer’s diagnosis and care.

Source: https://keck.usc.edu/news/usc-researchers-define-brain-scan-marker-to-better-classify-alzheimers-disease-related-changes/#:~:text=A%20team%20of%20researchers%20from,Alzheimer's%20disease%2C%20especially%20in%20Hispanic

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