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UCalgary research uncovers critical connections between sex hormones and brain health.

Published on: Feb 02, 2026

Cardiovascular and cerebrovascular health are closely linked, sharing common risk factors such as high blood pressure and interconnected biological pathways. As a result, dysfunction in the brain, heart, or blood vessels can directly influence the others.

Older women are known to have a higher risk of dementia, cardiovascular disease, and stroke than men, yet the biological reasons behind this disparity have remained unclear. New research led by Dr. Marc Poulin at the Cumming School of Medicine, published in the Journal of Physiology, offers important insight particularly for women’s health after menopause.

In a six-year study of 89 adults with an average age of 66, researchers found that women experienced greater increases in blood pressure and more rapid declines in cerebrovascular function over time compared with men. Although women initially showed better brain vascular health, this advantage diminished as aging progressed.

The study also identified strong links between sex hormone levels especially estrogen and testosterone and cerebrovascular function, suggesting that declining hormones after menopause may contribute to accelerated brain vascular aging. These findings highlight the need for more sex-specific research to better understand aging, hormone changes, and disease risk.

Source: https://libin.ucalgary.ca/news/ucalgary-research-shows-important-links-between-sex-hormones-and-brain-health

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