4th Edition 2026

McGill study findings may pave the way for novel longevity therapies and enhanced strategies for fall prevention.

Published on: Feb 23, 2026

A new study from McGill University has identified a direct mechanism behind age-related motor decline. Researchers found that reduced activity in Purkinje cells, key cerebellar neurons responsible for fine-tuning movement  leads to worsening gait, balance, and coordination.

In aging mice, lower Purkinje cell firing rates were linked to poorer performance on tasks such as beam walking and the Rotarod test. When scientists reduced neuron activity in young mice, their motor skills declined. When they increased neuron firing in older mice, coordination significantly improved.

• Purkinje cell dysfunction directly drives motor aging
• Restoring neuron activity can reverse coordination deficits
• Findings may support fall-prevention strategies
• Potential relevance for Alzheimer’s and other neurodegenerative diseases

The research opens promising avenues for therapies aimed at preserving mobility, independence, and health span in aging populations.

Source: https://www.mcgill.ca/newsroom/channels/news/findings-mcgill-study-could-lead-new-longevity-therapies-and-improved-fall-prevention-371349

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